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JAOA • Vol 106 • No 10 • October 2006 • 621-623
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CASE REPORT

Asymptomatic Thrombus Trapping in Vena Cava Filters: A Case Series

Oliver L. Gunter, MD; Ronald F. Sing, DO; Michael J. Rosen, MD; Kent W. Kercher, MD; B. Todd Heniford, MD

From the F.H. "Sammy" Ross, Jr Center (Drs Gunter and Sing); and the Department of Surgery, Carolinas Laparoscopic and Advanced Surgery Program (Drs Sing, Rosen, Kercher, and Heniford) at the Carolinas Medical Center–Carolinas HealthCare System in Charlotte, NC.

Address correspondence to Ronald F. Sing, DO, Department of Surgery, Carolinas Medical Center–Carolinas HealthCare System, PO Box 32861, Charlotte, NC 28232–2861. E-mail: ron.sing{at}carolinashealthcare.org

The prophylactic use of vena cava filters (VCFs) remains controversial. Class I data supporting the placement of prophylactic VCFs are lacking. In addition, there are concerns regarding the long-term effects of permanent VCF placement in patients with a relatively brief period of thromboembolic risk. Venous thromboembolism can be a lethal event, occurring without a prodrome. Yet, this condition is potentially preventable. The efficacy of VCFs is difficult to determine, as it is likely that when a VCF actually traps a thrombus, the event is clinically asymptomatic. We present three cases of asymptomatic thrombus trapping in VCFs, recognized through incidental radiographic studies.


   Case 1
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A 26-year-old man involved in a high-speed motor vehicle collision sustained traumatic brain injury, pulmonary contusions, a grade 2 liver laceration, extraperitoneal bladder rupture, pelvic fracture, and lower extremity fractures. He required mechanical ventilation for acute respiratory distress syndrome (ARDS) as well as skeletal traction, which prevented the placement of sequential compression devices. Prophylactic doses of heparin were contraindicated because of the patient's injuries and an unstable hemoglobin level. A vena cava filter (VCF) was inserted at the bedside in the intensive care unit on the second day postinjury. A computed tomographic scan (Figure 1) was obtained 5 days after VCF insertion to evaluate the patient for possible abdominal sepsis. The scan revealed an embolus trapped in the cone of the filter. The clot was nonocclusive and asymptomatic.


Figure 1
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  		Figure 1. Computed tomographic scan (axial image) showing a thrombus in the struts of a vena cava filter (arrow).

 

   Case 2
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A 14-year-old boy sustained a lateral compression fracture of his pelvis, bilateral femur fractures, and a lumbar spine fracture with resultant paraplegia when he was ejected from his seat during a motor vehicle collision. Acute respiratory distress syndrome required that he be given high-frequency oscillatory ventilation. A retrievable VCF was inserted on the third day postinjury. Sixty days after VCF insertion and 14 days after hospital discharge, the patient returned for removal of the VCF. A venogram obtained before removal of the filter showed the presence of two small clots in the VCF (Figure 2). The filter was removed, and a regimen of therapeutic anticoagulation was initiated.


Figure 2
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  		Figure 2. Contrast cavagram showing the tip of the vena cava filter (single arrow) and two thrombi (double arrows).

 

   Case 3
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A 26-year-old man involved in a motor vehicle accident sustained a traumatic subarachnoid hemorrhage and a spinal cord injury, resulting in incomplete tetraplegia. He required mechanical ventilation for ARDS caused by aspiration during the trauma. Vena cava filter placement was done at the bedside in the intensive care unit on the second day postinjury. Sixty days after insertion, the patient returned for VCF removal. A venogram obtained before VCF removal identified a large thrombus in the VCF (Figure 3). Therapeutic anticoagulation was started and, due to the size of the thrombus, the VCF was left in place as a permanent implant.


Figure 3
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  		Figure 3. Contrast cavagram showing the tip of the vena cava filter (black arrow) and the filter filled containing a thrombus (white arrows).

 

   Comment
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Despite adequate prophylaxis with subcutaneous heparin and lower extremity compression devices, venous thromboembolism, which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a frequent cause of morbidity and mortality in injured patients.1–4 Unfortunately, PE occurs without warning, and in severely injured patients, just one occurrence may be fatal. Although pharmacologic prophylaxis has been shown to decrease the incidence of both DVT and PE, it is not 100% protective, particularly in high-risk patients.5 To complicate matters, high-risk patients frequently have contraindications to even prophylactic doses of subcutaneous heparin because of concomitant injuries.

Rogers and colleagues6 identified clinical factors that contribute to high-risk stratification in a retrospective review of PE in patients with severe injuries. They reported that 92% of PEs occurred in patients with specific injuries, such as spinal cord injuries, head injuries, and long bone and pelvic fractures. An analysis from the American College of Surgeons' National Trauma Data Bank7 identified similar risk factors in addition to age (>40 years), venous injury, and mechanical ventilation for longer than 3 days, confirming the report by Rogers and colleagues,8 who found significant protection against PE in patients with prophylactic VCFs. It should be noted that all VCFs are considered prophylactic in that they prevent thrombi from reaching the pulmonary circulation; they do not treat DVT or PE. Although there are a relatively small number of patients in the study by Rogers and colleagues,8 their observations have been corroborated by those of other investigators.9–12 Based on the findings of these investigators, the Eastern Association for the Surgery of Trauma (East Northport, NY) developed the Practice Management Guidelines for the Prevention of Venous Thromboembolism in Trauma Patients,13 with a level 3 recommendation (ie, recommendation based on retrospective studies or expert opinion) for VCF insertion in very-high-risk patients.

Most prospective studies of injured patients with PE have been limited to symptomatic PE. The true incidence of PE may be greatly underestimated, however, as the illness is asymptomatic in most patients. Schultz and colleagues,14 who performed a prospective study of patients with Injury Severity Scores of 9 or higher, identified a 24% incidence of asymptomatic PE, including four patients with massive PE detected on contrast-enhanced computed tomography of the chest. Combes and colleagues,15 using autopsy-identified PE in patients who died in an intensive care unit, reported a 5.9% incidence of PE.

No method has been developed to determine when a VCF actually performs its function. It is our opinion that an acute vena caval occlusion is likely the entrapment of a large, possibly fatal PE, whereas the intimal overgrowth caused by the VCF itself leads to a more chronic occlusion. Large, randomized, prospective studies evaluating prophylactic insertion of VCFs are lacking at this time.

Although it is arguable that the clots described in the present case series were caused by the VCFs themselves, we contend that a thrombus trapped in the cone of the filter makes an embolic source more likely than a primary thrombus arising de novo within the filter. The laminar flow of blood is highest in the center of the vena cava and slowest at the periphery, where a primary thrombus would more likely form on the struts of the filter as a result of endothelial damage or stagnation of blood flow.16

The controversy over prophylactic VCF insertions continues.17 The present case series demonstrates that the filters inserted in injured patients are performing their intended task, thus lending support to the use of prophylactic VCFs. Further study is needed to define the role of VCFs in the absence of documented venous thromboembolism.

Submitted May 25, 2005; revision received October 4, 2005; accepted October 6, 2005.


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1. Shackford SR, Mackersie RC, Holbrook TL, Davis JW, Hollingsworth-Fridlund P, Hoyt DB, et al. The epidemiology of traumatic death: a population-based analysis. Arch Surg.1993; 128:571 –575.[Abstract/Free Full Text]

2. Fitts WT Jr, Lehr HB, Bitner RL, Spelman JW. An analysis of 950 fatal injuries. Surgery.1964; 56:663 –668.[Medline]

3. Knudson MM, Collins JA, Goodman SB, McCrory DW. Thromboembolism following multiple trauma. J Trauma.1992; 32:2 –11.[Medline]

4. O'Malley KF, Ross SE. Pulmonary embolism in major trauma patients. J Trauma. 1990;30:748 –750.[Medline]

5. Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;331:1601–1606. Available at: http://content.nejm.org/cgi/content/abstract/331/24/1601. Accessed September 15, 2006.

6. Rogers FB, Shackford SR, Wilson J, Ricci MA, Morris CS. Prophylactic vena cava filter insertion in severely injured trauma patients: indications and preliminary results. J Trauma.1993; 35:637 –641.[Medline]

7. Knudson MM, Ikossi DG, Khaw L, Morabito D, Speetzen LS. Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg. 2004;240:490 –498.[Medline]

8. Rogers FB, Shackford SR, Ricci MA, Wilson JT, Parsons S. Routine prophylactic vena cava filter insertion in severely injured trauma patients decreases the incidence of pulmonary embolism. J Am Coll Surg. 1995;180:641 –647.[Medline]

9. Gosin JS, Graham AM, Ciocca RG, Hammond JS. Efficacy of prophylactic vena cava filters in high-risk trauma patients. Ann Vasc Surg. 1997;11:100 –105.[Medline]

10. Velmahos GC, Kern J, Chan LS, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report—part II: analysis of risk factors and evaluation of the role of vena cava filters. J Trauma.2000; 49:140 –144.[Medline]

11. Carlin AM Tyburski JG, Wilson RF, Steffes C. Prophylactic and therapeutic inferior vena cava filters to prevent pulmonary emboli in trauma patients. Arch Surg.2002; 137:521 –527.[Abstract/Free Full Text]

12. Rodriguez JL, Lopez JM, Proctor MC, Conley JL, Gerndt SJ, Marx MV, et al. Early placement of prophylactic vena caval filters in injured patients at high risk for pulmonary embolism. J Trauma.1996; 40:797 –804.[Medline]

13. Rogers FB, Cipolle, MD, Velmahos G, Rozycki G, Luchette FA. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group [review]. J Trauma. 2002;53:142–164. Available at: http://www.east.org/tpg/dvt.pdf. Accessed September 15, 2006.

14. Schultz DJ, Brasel KJ, Washington L, Goodman LR, Quickel RR, Lipchik RJ, et al. Incidence of asymptomatic pulmonary embolism in moderately to severely injured trauma patients. J Trauma.2004; 56:727 –733.[Medline]

15. Combes A, Mokhtari M, Couvelard A, Trouillet JL, Baudot J, Henin D, et al. Clinical and autopsy diagnoses in the intensive care unit: a prospective study. Arch Intern Med.2004; 164:389 –392.[Abstract/Free Full Text]

16. Einav S, Bluestein D. Dynamics of blood flow and platelet transport in pathological vessels. Ann N Y Acad Sci.2004; 1015:351 –366.[Medline]

17. Hann CL, Streiff MB. The role of vena caval filters in the management of venous thromboembolism. Blood Rev.2005; 19:179 –202.[Medline]





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