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Department of Family Practice College of Medicine University of Vermont Middlebury

I thank Dr Stefano for elaborating on the mechanisms proposed in our June 2005 original contribution.¹ There is "NO" doubt that future research collaborations will open new doors for the osteopathic physicians' use of osteopathic manipulative treatment. Basic scientists with excellent pedigrees are conducting endocannabinoid research at osteopathic medical schools.^2,3 Osteopathic medicine needs outcomes-based research, but we also need to explore the mechanisms by which our treatments work.

References
1. McPartland JM, Giuffrida A, King J, Skinner E, Scotter J, Musty RE. Cannabimimetic effects of osteopathic manipulative treatment. J Am Osteopath Assoc. 2005;105:283–291. Available at: http://www.jaoa.org/cgi/content/full/105/6/283. Accessed September 27, 2006.

2. Darmani NA. Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. Methods Mol Med. 2006;123:169 –189.[Medline]

3. Ogawa A, Meng ID. The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons. Neuroscience. Epub August29 , 2006. In press.

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