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Journal of the American Osteopathic Association, Vol 99, 8 Suppl, 10S-10S
Copyright © 1999 by American Osteopathic Association

Articles

NSAIDs and the gastrointestinal tract: an update on recent progress

GJ Silverman

This article outlines the mechanisms involved in specific cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition as they relate to the safety of nonsteroidal anti-inflammatory drug (NSAID) use. New advancements in COX-2 technology appear to improve the safety profile of NSAID therapy. Gastroenterologic issues such as ulcer disease and liver disease as related to these novel new medications are reviewed.




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Copyright © 1999 by the American Osteopathic Association.