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Journal of the American Osteopathic Association, Vol 94, Issue 5, 414-414
Copyright © 1994 by American Osteopathic Association

Case Reports

Splenic hypofunction in systemic lupus erythematosus

JC Childs, RA Adelizzi, MB Dabrow, and N Freed

Systemic lupus erythematosus is a relatively common autoimmune disease in the United States. Hyposplenism is infrequently described in patients with systemic lupus erythematosus. It is seen in up to 5% of patients and is thought to be caused by vasculitic changes within the spleen. The diagnosis of hyposplenism can be made easily by identifying Howell-Jolly bodies on a peripheral blood smear. The authors describe a patient with systemic lupus erythematosus associated with hyposplenism and discuss possible diagnostic and treatment implications.




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Copyright © 1994 by the American Osteopathic Association.