Condyloma acuminatum is a viral infection of near epidemic proportions. Both men and women are affected equally. Most lesions are on the external genitalia and the mucous membranes of the urethra or the vagina. A rare occurrence of condyloma acuminata is involvement of the urinary bladder. To date, only 11 cases have been reported. We describe two additional cases, both with bilateral ureteral obstruction. Current urologic management and review of the literature are presented.