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Address correspondence to B. Lee Peterlin, DO, 245 N 15th St, MS 423, Philadelphia, PA 19102-1101. E-mail: lee.peterlin{at}drexelmed.edu

Although it has long been known that fasting or the consumption of certain foods can trigger headaches, abdominal and total body obesity have only recently been linked to migraine. Several adipocytokines appear to play an integral role in feeding and obesity—and have also been linked to pain. Among these proteins are adiponectin and leptin. The author reviews the regulation of adipose tissue and feeding and provides an in-depth examination of adiponectin and leptin and their association with migraine.