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JAOA • Vol 108 • No 8 • August 2008 • 409-411
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CASE REPORT

Pathological Laughter in a Patient With Multiple Sclerosis

 Carl Hoegerl, DO; Sharon Zboray, MSN, CRNP

From the Department of Neurology at the Geisinger Medical Center in Danville, Pa.

Address correspondence to Carl Hoegerl, DO, Geisinger Medical Center, 100 N Academy Ave 14-05, Danville, PA 17822-0001. E-mail: hoegerl{at}yahoo.com

Pseudobulbar affect—such as pathological laughter or crying—is associated with several different neurologic diseases and is most frequently seen in patients with Alzheimer disease. However, many physicians do not recognize it as a symptom associated with multiple sclerosis. The present report describes a case of pathological laughter in a 56-year-old man who was diagnosed as having multiple sclerosis 20 years earlier.






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