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From the Department of Surgery at the University of North Texas Health Science Center—Texas College of Osteopathic Medicine in Fort Worth.

Address correspondence to Lori A. Jenkins, OMS IV, 3500 Camp Davie Blvd, Fort Worth, TX 76107-2970. E-mail: lojenkin{at}hsc.unt.edu

Solitary fibrous pleural tumors are rare masses of mesenchymal origin that may be mistaken for mesothelioma. A positive staining of vimentin, negative staining of cytoplasmic keratin, and expression of the CD34 antigen can confirm the presence of a solitary fibrous pleural tumor. Although most tumors of this type are benign, they possess a malignant potential and thus should be excised. We report a case of a 63-year-old man who had an inconclusive biopsy of a lung lesion 15 years ago. Further testing after excision revealed a solitary fibrous pleural tumor. A brief discussion of the clinical presentation and incidence of these tumors is included.