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JAOA • Vol 108 • No 4 • April 2008 • 211-213
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CASE REPORT

Paradoxical Response to Levalbuterol

LT Sarah E. Broski, DO, MC, USN; CAPT Dennis E. Amundson, DO, MC, USN

From the Pulmonary and Critical Care Department at the Naval Medical Center San Diego in San Diego, Calif.

Address correspondence to CAPT Dennis E. Amundson, DO, MC, USN, c/o Clinical Investigation Department (KCA), Naval Medical Center San Diego, 34800 Bob Wilson Dr, Suite 5, San Diego, CA 92134-1005. E-mail: deamundson{at}nmcsd.med.navy.mil

Asthma is a common condition that can substantially affect patients' quality of life. Although several drugs, most commonly β-adrenergic agonists, alleviate symptoms of asthma, they may cause paradoxical bronchospasm or paradoxical bronchoconstriction. Levalbuterol hydrochloride—a pure form of the (R)-stereoisomer in racemic albuterol—eliminates the adrenergic properties that can cause such adverse effects. However, we report a case of paradoxical bronchoconstriction in a 36-year-old man who was recently diagnosed as having new-onset asthma and was treated with levalbuterol.







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