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A number of organizations have advised against the use of placebo substitution, including the American Pain Society, Agency for Healthcare Policy and Research, World Health Organization, Healthcare Facilities Accreditation Program, Joint Commission on Accreditation of Healthcare Organizations, Education for Physicians on End-of-Life Care Project (cosponsored by the American Medical Association and The Robert Wood Johnson Foundation), American Nursing Association, and the American Society of Pain Management Nurses.

This white paper describes the literature and rationale in support of the American Osteopathic Association's (AOA's) position on the controversial subject of the use of placebos for pain management in terminally ill patients.

The following policy statement was adopted by the AOA's House of Delegates in 2005. This statement was drafted by the association's Council on Palliative Care Issues, which at that time was called the End-of-Life Care Committee.

This statement has been modified to adhere to the house style of JAOA—The Journal of the American Osteopathic Association.