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From the Department of Family Medicine at the University of North Texas Health Science Center—Texas College of Osteopathic Medicine in Fort Worth.

Address correspondence to Brent W. Sanderlin, DO, Department of Family Medicine, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, 3400 Camp Bowie Blvd, Fort Worth, TX 76107-2729.E-mail: bsanderl{at}hsc.unt.edu

This article provides an introductory step-by-step process to appraise clinical practice guidelines. The authors introduce these principles using a systematic approach and case-based format. The process of assessing the validity of clinical practice guidelines, determining their importance, and applying them to an individual patient is reviewed. The concepts of study population homogeneity, equal treatment, and study completeness are discussed to help physicians determine the validity of clinical practice guidelines. Finally, information that is learned from the previously mentioned steps is applied to patient care. Study generalizability and the role of patient values, expectations, and concerns are also addressed. The skills learned from appraising clinical practice guidelines in the manner outlined provides a solid basis for life-long learning and improved patient care.