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JAOA • Vol 104 • No 9_suppl • September 2004 • 14-16
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Utility of Currently Available Modes of Therapy in Reaching Lipid Goals

Kelly Anne Spratt, DO; Margo A. Denke, MD

University of Pennsylvania Health System, Cardiovascular Division, Philadelphia Heart Institute in Pennsylvania (Dr Spratt) and The University of Texas Health Science Center at San Antonio (Dr Denke).
Dr Spratt is on the speakers bureau for Merck & Co, Pfizer Inc, and AstraZeneca Pharmaceuticals LP. Dr Denke is on the advisory board of Merck/Schering–Plough Pharmaceuticals and on the speakers bureau for Merck & Co and Merck/Schering–Plough Pharmaceuticals. She also is an advisor and a coauthor on the Ezetimibe Add-on to Statin for Effectiveness (EASE) trial.

Address correspondence to Kelly Anne Spratt, DO, Clinical Assistant Professor of Medicine, University of Pennsylvania Health System, Cardiovascular Division, Philadelphia Heart Institute, Second Floor, 39th & Market Streets, Philadelphia, PA 19104.E-mail: kspratt{at}uphs.upenn.edu

The National Cholesterol Education Program Adult Treatment Panel III lipid management guidelines emphasize the importance of matching the intensity of lipid modification therapy to each patient's risk of coronary heart disease. For many patients who are at low risk, nonpharmacologic interventions such as diet, exercise, and smoking cessation can be effective lipid-lowering strategies. However, many patients require the addition of drug therapy to achieve lipid targets. Currently available lipid-modifying drugs include bile acid sequestrants, fibrates, nicotinic acid, cholesterol absorption inhibitors, and statins. In addition, nonprescription agents such as plant stanols and sterols are available to modify plasma lipid levels. These agents can be used individually or coadministered to achieve lipid goals.







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