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Correspondence to Murray H. Rosenthal, DO, Medical Director and CEO, BMR HealthQuest, 3625 Ruffin Rd, Suite 100, San Diego, CA 92123-1841.E-mail: rosenthal{at}bmrhealthquest.com

Depression is common in medically ill patients, and it presents a particular challenge to the primary care physician. Depression may exacerbate cardiovascular disease, diabetes, and irritable bowel syndrome. Also, it may cause a poorer prognosis of each of these disorders. It is therefore recommended that depression screening be incorporated into a treatment plan for all these conditions, because treatment of depressive symptoms will improve patient quality of life and the outcome of other comorbid illness.