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Dr Clearfield is a professor of medicine and associate dean for clinical research at the University of North Texas Health Science Center at Fort Worth-Texas College of Osteopathic Medicine. Dr Clearfield represented the American Osteopathic Association, a member organization of the National Cholesterol Education Program Coordinating Committee, which approved the Third Report of the National Cholesterol Education Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Dr Clearfield is a member of the JAOA Editorial Advisory Board

Address correspondence to Michael B. Clearfield, DO, FACOI, Department of Internal Medicine, University of North Texas Health Science Center at Fort Worth-Texas College of Medicine, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2644.E-mail: mclearfi{at}hsc.unt.edu

This review of lipid-lowering trials looks at both the primary and secondary prevention of coronary heart disease. It also introduces evidence pointing toward the emerging importance of nonlipid risk factors in the pathogenesis of atherosclerosis. This review is designed to enhance the primary care physician's working knowledge of the evidence supporting the importance of LDL-C reduction and the central role of statin therapy in the reduction of the risk of coronary heart disease, as well as provide a greater understanding of emerging risk factors.